The Tigers have opened up as a substantial favorite to pick up their seventh straight win over the rival Gamecocks.
Clemson has opened up as a 12.5 point favorite, according to Draft Kings.
Coming off their most complete game of the season in a dominating win over Wake Forest, Clemson will now look to take that momentum to Columbia against the 6-5 Gamecocks. South Carolina is coming off a win over Auburn, which made them bowl eligible.
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