The Tigers have opened up as a substantial favorite to pick up their seventh straight win over the rival Gamecocks.
Clemson has opened up as a 12.5 point favorite, according to Draft Kings.
Coming off their most complete game of the season in a dominating win over Wake Forest, Clemson will now look to take that momentum to Columbia against the 6-5 Gamecocks. South Carolina is coming off a win over Auburn, which made them bowl eligible.
Depth Charts Released for Notre Dame, Clemson
Clemson and Notre Dame have released depth charts ahead of this weekend’s matchup at Death Valley.
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Clemson Home Underdog for Second Time This Season
For the second time this season, Clemson will be an underdog at home.
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Clemson Opens as Substantial Road Favorite Over NC State
Despite Clemson’s astonishing loss to Miami, the Tigers will head to Raleigh next week favored over NC State.
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